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Objective: To explore the inhibition effective of the SDZ on Iovo cell growth of colon cancer in vitro. Methods:The apoptosis was observed by Hoechst fluorescein stain and transmission electron microscope. Results: The apoptosis was observed after the Iovo ceils treated by SDZ (1000 μg/mL) for 24 h. The rate of apoptosis was 30.2%. Conclusion: The apoptosis of Iovo cells can be induced by SDZ in vitro.