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目的探讨滤泡树突细胞肉瘤的临床病理学特征、诊断及鉴别诊断,提高对该肿瘤的认识和诊断水平。方法对5例滤泡树突状细胞肉瘤进行光镜观察和免疫组化标记,并复习文献加以分析。结果瘤细胞梭形或卵圆形,常呈巢状、旋涡状和席纹状排列,细胞边界不清,呈合体状,核圆形或卵圆形,核膜清晰,染色质点彩状或空泡状,有小核仁。瘤细胞间常混有大量小淋巴细胞。免疫表型:瘤细胞CD21、CD23、CD35阳性。结论滤泡树突状细胞肉瘤是一种罕见的恶性肿瘤,诊断较困难,正确的诊断及鉴别诊断须依赖于免疫组化。
Objective To investigate the clinicopathological features, diagnosis and differential diagnosis of follicular dendritic cell sarcoma, and to improve the understanding and diagnosis of this tumor. Methods 5 cases of follicular dendritic cell sarcoma were observed by light microscopy and immunohistochemistry, and reviewed the literature to be analyzed. Results The tumor cells were fusiform or oval, often arranged in nests, whorls and stripes. The cells had unclear borders and had a complex shape with a round or oval nucleus. The nuclear membrane was clear and the chromatin spots were colored or empty Bubbly, with small nucleolus. Tumor cells are often mixed with a large number of small lymphocytes. Immunophenotype: tumor cells CD21, CD23, CD35 positive. Conclusions Follicular dendritic cell sarcoma is a rare malignant tumor which is difficult to diagnose. The correct diagnosis and differential diagnosis depend on immunohistochemistry.