沙门菌(Salmonella)是革兰氏阴性的兼性胞内菌,可引起其广泛宿主的一系列疾病,严重时可导致全身性感染,威胁生命安全。沙门菌致病岛2(SPI2)是与沙门菌全身性感染密切相关的重要毒力基因簇,其编码的Ⅲ型分泌系统2(T3SS2)在沙门菌侵入宿主细胞后开始组装合成,经该装置分泌的多种效应蛋白对沙门菌在宿主细胞内的生存和增殖起着重要作用。近些年来,与沙门菌T3SS2相关的研究一直都是病原微生物领域关注的焦点之一。本文简要综述了SPI2的基因特征、SPI2基因表达的调控、T3SS2的结构和组成、T3SS2的效应蛋白及与T3SS2相关的疫苗研究等方面的主要研究进展。 Salmonella is a Gram-negative facultative intracellular bacterium that causes a wide range of diseases in a wide range of hosts, leading to generalized infections and life-threatening in severe cases. Salmonella pathogenicity island 2 (SPI2), an important virulence gene cluster closely related to systemic infection with Salmonella, encodes type III secretion system 2 (T3SS2) which begins to assemble and synthesize after Salmonella invades the host cells. Through the device Secreted multi-effector proteins play an important role in the survival and proliferation of Salmonella in host cells. In recent years, the research related to Salmonella T3SS2 has always been one of the focuses in the field of pathogenic microorganisms. This review summarizes the main research progress of SPI2 gene, the regulation of SPI2 gene expression, the structure and composition of T3SS2, the effector protein of T3SS2 and the vaccine related to T3SS2.