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众所周知,神经激素异常与充血性心力衰竭的病理生理密切相关。改善充血性心力衰竭预后的成功方法主要是阻断神经激素系统的激活。肾素-血管紧张素-醛固酮系统和交感神经系统的拮抗剂和阻断剂显著改善了充血性心力衰竭患者的预后。心力衰竭时过量分泌的精氨酸血管加压素可能加速充血性心力衰竭的病理进程。精氨酸血管加压素受体拮抗剂阻断精氨酸血管加压素的作用,是一种治疗充血性心力衰竭的新方法,可能使患者获益。
As we all know, neurohormonal abnormalities and the pathophysiology of congestive heart failure are closely related. The success of improving the prognosis of congestive heart failure is mainly to block the activation of the neurohormonal system. Antagonists and blockers of the renin-angiotensin-aldosterone system and the sympathetic nervous system significantly improve the prognosis of patients with congestive heart failure. Arginine vasopressin, which is overexpressed in heart failure, may accelerate the pathological progression of congestive heart failure. Arginine vasopressin receptor antagonists block the action of arginine vasopressin and are a novel method of treating congestive heart failure that may benefit patients.