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目的:观察补康灵预防非小细胞肺癌患者化疗后白细胞减少症的疗效。方法:将120例非小细胞肺癌初治患者随机分为两组,治疗组63例,采用TP方案化疗,联合口服补康灵治疗;对照组57例仅采用TP方案化疗,观察化疗期间两组白细胞的变化、重组人粒细胞集落刺激因子(G-CSF)使用量、白细胞减少继发感染发生情况及生活质量评分情况。结果:治疗组在化疗过程中白细胞减少20例(31.75%)明显少于对照组34例(59.65%)(P<0.05),两组G-CSF用量、生活质量改善状况以及白细胞减少继发感染发生例数之间的均有统计学差异(P<0.05)。结论:补康灵可有效预防非小细胞肺癌化疗所发生的白细胞减少症。
Objective: To observe the effect of Bukangling in preventing leukopenia after chemotherapy in patients with non-small cell lung cancer. Methods: A total of 120 patients with non-small cell lung cancer were randomly divided into two groups. The treatment group (63 cases) was treated with TP regimen combined with oral bupropion. The control group (57 cases) received TP regimen only. Leukocyte changes, the use of recombinant human granulocyte-colony stimulating factor (G-CSF), the incidence of secondary leukopenia and quality of life scores. Results: The number of leukopenia in the treatment group was significantly lower than that in the control group (20 cases, 31.75%, 34 cases, 59.65%) (P <0.05). The G-CSF dosage, quality of life improvement and secondary leukopenia infection Between the occurrence of the number of cases were statistically significant (P <0.05). Conclusion: Bukangling can effectively prevent leukopenia caused by non-small cell lung cancer chemotherapy.