肿瘤细胞对多种化疗药物产生交叉耐药性,称多药耐药(multidrug resistance,MDR)是造成肿瘤化疗失败的主要原因。有关资料统计,肿瘤年病死率中,属内在性多药耐药(intrinsic MDR)的肿瘤,包括消化器官的胃癌,肠癌,肝癌等,呼吸系统的肺癌,泌尿系统的肾癌以及大脑和中枢神经系统肿瘤约占61%,属获得性多药耐药(acquired MDR)的 Tumor cells are cross-resistant to a variety of chemotherapeutic drugs, saying that multidrug resistance (MDR) is the main cause of tumor chemotherapy failure. About statistics, the annual cancer mortality, is an intrinsic MDR of tumors, including gastrointestinal cancer digestive organs, colon cancer, liver cancer, lung cancer of the respiratory system, urinary tract renal cell carcinoma and the brain and central About 61% of nervous system tumors, is an acquired multidrug resistance (acquired MDR)