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胆汁酸不仅能抑制结肠对水和电解质的吸收,还能促使结肠分泌。回肠吸收胆汁酸障碍时,大量胆汁酸到达结肠所引起腹泻称作胆汁酸性腹泻。该类腹泻可分为三型。以Ⅰ型最常见,大多继发于回肠末端切除后;Ⅱ型为先天性回肠选择性胆汁酸运转缺陷;Ⅲ型多伴有与回肠疾病无关的消化道疾病。回肠末端切除<100公分者可发生胆汁酸性腹泻,切除范围>100公分者则腹渴的原因不是胆汁酸而是脂肪酸(脂肪泻)。本病的诊断除依靠病史和实验室检查外,尚可做胆酪胺试验性治疗,如效果显著,提示有本病的可能,需作其他检查以证实之。口服胆酪胺是治疗本病的主要方法。
Bile acids not only inhibit the colon’s absorption of water and electrolytes, but also promote colon secretion. Ileal absorption of bile acid disorders, a large number of bile acids to reach the colon caused by diarrhea called bile acid diarrhea. This type of diarrhea can be divided into three types. Type I is the most common, mostly secondary to the end of the ileum resection; type II congenital ileal selective bile acid deficiencies; type III and more associated with ileum disease-related gastrointestinal diseases. Ileal end resection of <100 cm may occur bile acid diarrhea, resection range> 100 cm, then the reason is not the thirst of bile acid but fatty acids (steatorrhea). In addition to rely on the diagnosis of the disease history and laboratory tests, but also can do experimental treatment of bovine tyramine, such as the effect is significant, suggesting that the possibility of the disease, to be confirmed by other tests. Oral administration of bile tyramine is the main method of treatment of this disease.