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目的比较单阻断法和双阻断法测定呼吸道疾病婴幼儿肺顺应性(Crs)和呼吸道阻力(Rrs)的差异。方法选择门诊送检肺功能测定的82例呼吸道疾病婴幼儿,应用Master Screen Paed型肺功能仪对其进行潮气呼吸环测定,并分别采用单阻断法和双阻断法测定其Crs和Rrs。分析参数包括达峰时间比值(TPTEF/TE)、达峰容积比值(VPEF/VE)及单阻断法和双阻断法测定的Crs和Rrs。应用SPSS 11.5软件进行统计学分析。结果 82例患儿的潮气呼吸参数TPTEF/TE为(23.2±11.4)%,VPEF/VE为(25.9±9.5)%。双阻断法测定的Crs显著高于单阻断法[(18.06±12.21)mL.kg-1.kPa-1 vs(14.40±6.93)mL.kg-1.kPa-1,P=0.001],而2种方法测定的Rrs比较差异无统计学意义[(3.66±1.47)kPa.L-1.s-1 vs(3.82±1.91)kPa.L-1.s-1,P=0.288]。经潮气呼吸环测定的TPTEF/TE、VPEF/VE与单阻断法测定的Rrs均呈负相关(r=-0.245,P=0.026;r=-0.257,P=0.020),但与双阻断法测定的Rrs均无相关性。结论在测定Crs和Rrs时,应用单阻断法和双阻断法联合测定有助于更全面分析呼吸道疾病婴幼儿的肺功能状态。
Objective To compare the differences of lung compliance (Crs) and respiratory resistance (Rrs) in infants and young children with respiratory diseases by single-block and double-block assays. Methods Eighty-two respiratory disease infants and young children with pulmonary function tests were selected for outpatient examination. The Master Screen Paed-type pulmonary function test instrument was used to measure the respirator ring. The Crs and Rrs were measured by single-block and double-block method respectively. Analytical parameters included peak time ratio (TPTEF / TE), peak volume ratio (VPEF / VE), and Crs and Rrs measured by single-block and double-block assays. SPSS 11.5 software was used for statistical analysis. Results The tidal respiratory parameters TPTEF / TE of 82 children were (23.2 ± 11.4)% and the VPEF / VE was (25.9 ± 9.5)%. Crs measured by the double-block method was significantly higher than that of the single-block method [(18.06 ± 12.21) mL.kg-1.kPa-1 vs (14.40 ± 6.93) mL.kg-1.kPa-1, P = 0.001] There was no significant difference in Rrs between the two methods [(3.66 ± 1.47) kPa.L-1.s-1 vs (3.82 ± 1.91) kPa.L-1.s-1, P = 0.288]. The TPTEF / TE and VPEF / VE measured by the tidal breathing ring were negatively correlated with the Rrs measured by single-block method (r = -0.245, P = 0.026; r = -0.257, P = 0.020) Rrs method determination of no correlation. Conclusion In the determination of Crs and Rrs, the combination of single-block assay and double-block assay is helpful for a more comprehensive analysis of pulmonary function in infants and young children with respiratory diseases.