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目的:研究非瓣膜性房颤患者血小板微粒(PMP)的数量变化及其与超敏C反应蛋白(Hs-CRP)的相关性。方法:选取109例住院非瓣膜性心房颤动患者作为观察组,永久性房颤25例、持续性房颤27例、阵发性房颤57例,及44例同期住院窦性心律患者作为对照组。采用流式细胞术对血浆中PMP数量进行检测,同时采用免疫比浊法测定血清Hs-CRP水平。结果:(1)房颤各组PMP水平均高于对照组(P<0.05);其中永久性房颤组PMP水平高于阵发性房颤组,差异有统计学意义(P<0.05);(2)房颤各组Hs-CRP水平均高于对照组(P<0.05),并且永久性房颤组高于持续性房颤组及阵发性房颤组(P<0.001);(3)PMP与Hs-CRP呈正相关,差异具有统计学意义(r=0.204,P=0.033)。结论:PMP可能参与房颤患者血栓形成的病理生理过程和增强炎症反应,进一步促进血栓形成。
Objective: To study the changes of platelet microparticles (PMP) in patients with nonvalvular atrial fibrillation and its correlation with hypersensitive C-reactive protein (Hs-CRP). Methods: A total of 109 patients with non-valvular atrial fibrillation were selected as the observation group. Among them, 25 were permanent atrial fibrillation, 27 were persistent atrial fibrillation, 57 were atrial fibrillation and 44 were hospitalized with sinus rhythm. . The amount of PMP in plasma was detected by flow cytometry, and the serum Hs-CRP level was measured by immunoturbidimetry. Results: (1) The levels of PMP in all groups were significantly higher than those in control group (P <0.05). PMP level in permanent AF group was higher than that in paroxysmal atrial fibrillation group (P <0.05). (2) The levels of Hs-CRP in each group were higher than those in the control group (P <0.05), and were higher in permanent AF group than those in persistent AF group and paroxysmal atrial fibrillation group (P <0.001) ) PMP was positively correlated with Hs-CRP, the difference was statistically significant (r = 0.204, P = 0.033). Conclusion: PMP may be involved in the pathophysiology of thrombosis in patients with AF and enhance the inflammatory response, further promoting thrombosis.