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自抗癌药物投入使用以来,引起二次癌变的报道不断增多。随着新的化学抗癌物的数量、品种及效能的增加和它们所产生的缓解期延长,对它们可能致癌的性质及程度进行评定也日趋重要。根据在人和实验动物体内的药—癌关系把可能在人体内致癌的药物按Hoover和Fraumeni的建议分成四类:(1)动物体内有致癌性并和人的致癌有关(如某些烷化剂);(2)实验动物有致癌
Reports of secondary carcinogenesis have been increasing since the use of anticancer drugs. With the increase in the number, species, and potency of new chemical anti-cancer agents and the prolonged remission period they generate, it is increasingly important to assess the nature and extent of their carcinogenicity. According to the drug-cancer relationship between humans and experimental animals, drugs that may be carcinogenic in the human body are classified into four categories according to the recommendations of Hoover and Fraumeni: (1) The animals are carcinogenic and related to human carcinogenesis (such as certain alkylation (2) Experimental animals have carcinogenesis