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目的:探讨低分子肝素联合硝酸甘油治疗不稳定型心绞痛的临床治疗效果。方法:选择我院2009年9月～2011年9月不稳定型心绞痛患者82例,将以上患者随机分为观察组和对照组。对照组患者给予血管紧张素转化酶抑制剂、钙通道阻滞剂以及他汀类调脂药物等,同时给予硝酸甘油10mg加入5%葡萄糖注射液250ml中静脉滴注,每天1次,连续应用7天。观察组在对照组用药基础上给予低分子肝素钙2500U皮下注射,每隔12小时1次,连续应用7天。2组均治疗3周。观察2组患者在治疗期间心绞痛发作情况,包括发作次数,每次发作持续时间,同时对心电图定期检测;观察2组患者治疗期间是否有出血倾向等不良反应发生。结果:观察组总有效率为95.1%,对照组总有效率为78.0%,2组总有效率比较,差异有统计学意义(P<0.05)。结论:低分子肝素联合硝酸甘油能够显著改善不稳定型心绞痛患者临床症状和体征,临床治疗效果显著,值得借鉴。
Objective: To investigate the clinical effect of low molecular weight heparin combined with nitroglycerin in the treatment of unstable angina pectoris. Methods: 82 cases of unstable angina pectoris were selected from September 2009 to September 2011 in our hospital. The above patients were randomly divided into observation group and control group. Patients in the control group were given angiotensin converting enzyme inhibitors, calcium channel blockers and statin lipid-lowering drugs. Meanwhile, 10 mg of nitroglycerin and 250 ml of 5% glucose injection were given intravenously once daily for 7 days . The observation group was given subcutaneous injection of low molecular weight heparin calcium 2500U on the basis of the control group, once every 12 hours for 7 consecutive days. Both groups were treated for 3 weeks. The incidence of angina pectoris, including the number of seizures and the duration of each seizure, were also observed. The electrocardiogram was detected regularly. The adverse reactions such as bleeding tendency were observed during the treatment in the two groups. Results: The total effective rate was 95.1% in the observation group and 78.0% in the control group. The total effective rate in the two groups was statistically significant (P <0.05). Conclusion: Low molecular weight heparin combined with nitroglycerin can significantly improve the clinical symptoms and signs of unstable angina pectoris patients. The clinical curative effect is significant and it is worth learning from.