一,临床前药效学评价的概念、目的、内容和要求药效动力学(简称药效学 Pharmacodynamics)研究药物对机体的作用规律.临床前药效学评价是在新药做临床试用以前要做的药效学工作.临床前药效学评价的目的是证实已经发现的新药的予期疗效,可能时还应阐明其作用原理.临床前药效学评价的内容主要有两个方面:(一)特殊药效学研究新药的主要药理作用,即予期用于临床治疗的药理作用.例如吗啡代用药的镇痛作用,阿托品类药物的解痉作用.如果可能时还应阐明主要药理 First, the preclinical pharmacodynamic evaluation of the concept, purpose, content and requirements Pharmacodynamics (Pharmacodynamics for short) to study the role of drugs on the body’s law. Pre-clinical pharmacodynamic evaluation is to do in the clinical trial of new drugs to be done Pharmacodynamic efficacy of pre-clinical pharmacodynamic evaluation is to confirm the expected efficacy of new drugs have been found, when possible, should also clarify its role in the principle of preclinical pharmacodynamic evaluation of the content of two aspects: (a) Special pharmacodynamics studies the main pharmacological effects of new drugs, which are pharmacological effects that are expected to be used clinically for treatment, such as analgesic effects of morphine substitutes, antispasmodic effects of atropines, and, if possible, the main pharmacological