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目的探讨前列地尔对肺心病合并肺动脉高压患者血氧分压及血流动力学的影响方法采用血气分析仪测定40例肺心病合并肺动脉高压患者应用前列地尔治疗前后的动脉血氧分压及采用彩色多普勒超声心动仪测定应用前列地尔治疗前后的血流动力学指标。结果应用前列地尔治疗能明显改善肺心病合并肺动脉高压患者的动脉血氧分压及血流动力学指标,治疗前后差异有统计学意义。结论前列地尔可显著提高肺心病合并肺动脉高压患者的动脉血氧分压,改善氧合,明显降低肺动脉压(PAP),增加心脏指数(CI)。
Objective To investigate the effects of alprostadil on the blood oxygenation and hemodynamics in patients with pulmonary heart disease complicated with pulmonary hypertension.Methods Blood gas analyzer was used to measure the partial pressure of arterial oxygen in 40 patients with pulmonary heart disease and pulmonary hypertension before and after the application of alprostadil, Color Doppler echocardiography was used to measure the hemodynamic parameters before and after the application of alprostadil. Results Application of alprostadil treatment can significantly improve pulmonary heart disease patients with pulmonary hypertension and arterial partial pressure of oxygen and hemodynamic indicators, the difference was statistically significant before and after treatment. Conclusion Alprostadil can significantly improve arterial oxygen tension, improve oxygenation, decrease pulmonary artery pressure (PAP) and increase cardiac index (CI) in pulmonary heart disease patients with pulmonary hypertension.