Shally等阐明了下丘脑GnRH的结构并人工合成成功,为生殖生理学的快速发展及对某些疾病的理解树立了里程碑。经过十年研究,已证明GnRH及其显效性、拮抗性类似物有重要的临床意义。在调节促性腺激素(GTH)的分泌中,下丘脑GnRH的脉冲样释放特征对于理解垂体-性腺轴的激活,对于在内源性GnRH缺乏的患者中诱发排卵提供了生理基础。GnRH及其显效剂持续治疗“反向调节”GTH分泌的发现,为发展新的避孕法提供了新途径;为各种甾体依赖性疾病如青春期早熟与癌症,提供了诱 Shally et al. Clarified the structure of the hypothalamus GnRH and succeeded in its synthesis, setting a milestone for the rapid development of reproductive physiology and understanding of certain diseases. After a decade of research, it has been demonstrated that GnRH and its potent and antagonistic analogues have important clinical implications. The pulsatile release profile of hypothalamic GnRH in regulating the secretion of gonadotropin (GTH) is an understanding of the activation of the pituitary-gonadal axis and provides a physiological basis for the induction of ovulation in endogenous GnRH-deficient patients. The discovery that GnRH and its apparent agents continue treatment of “inversely regulated” GTH secretion provides a new avenue for the development of new methods of contraception; it provides lures for a variety of steroid-dependent diseases such as precocious puberty and cancer