论文部分内容阅读
大量的实验研究表明,T细胞的活化需要两个信号的参与:一个是TCR接受抗原递呈细胞(antigen-presenting cells,APC)传导的MHC-抗原肽信号,另一个是细胞膜表面黏附分子提供的协同刺激信号(或称第二信号)。缺乏第二信号,不仅不能使T细胞充分活化,反而会诱导T细胞无能或引发其程序性
A large number of experimental studies have shown that the activation of T cells requires the participation of two signals: one is TCR receiving antigen-presenting cells (APC) -conducted MHC-antigen peptide signal and the other is cell surface membrane adhesion molecules Collaborative stimulation signal (or second signal). The lack of a second signal not only does not allow sufficient activation of T cells, but rather induces T cell incompetence or induces programmedness