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目的探讨胃癌组织中MMP-2的表达与微血管密度(MVD)的关系。方法采用免疫组化检测60例胃腺癌组织(胃癌组)、40例癌旁胃黏膜不典型增生组织(癌旁组)和20例正常胃黏膜组织(对照组)中MMP-2和MVD的表达情况,分析两者的关系。结果胃癌组MMP-2阳性率为75.00%,高于癌旁组的45.00%和对照组的15.00%(P<0.01)。胃癌组MVP为45.68±8.40,高于癌旁组的36.68±7.15和对照组的19.26±8.28(P<0.01)。MMP-2和MVD的表达与胃癌的浸润深度和淋巴结转移密切相关(P<0.01)。胃癌组织中MMP-2的表达与MVD呈正相关(r=0.76,P<0.01)。结论 MMP-2和MVD在胃腺癌组织中高表达,在胃癌的发生、发展中起重要作用。
Objective To investigate the relationship between MMP-2 expression and microvessel density (MVD) in gastric cancer. Methods Immunohistochemistry was used to detect the expression of MMP-2 and MVD in 60 cases of gastric adenocarcinoma (gastric cancer group), 40 cases of paraneoplastic gastric dysplasia (paracancer group) and 20 cases of normal gastric mucosa (control group) Situation, analyze the relationship between the two. Results The positive rate of MMP-2 in gastric cancer group was 75.00%, which was higher than 45.00% in paracancer group and 15.00% in control group (P <0.01). The MVP in gastric cancer group was 45.68 ± 8.40, which was higher than that in paracancer group (36.68 ± 7.15) and control group (19.26 ± 8.28, P <0.01). The expression of MMP-2 and MVD was closely related to the depth of invasion and lymph node metastasis (P <0.01). The expression of MMP-2 in gastric cancer tissues was positively correlated with MVD (r = 0.76, P <0.01). Conclusion The high expression of MMP-2 and MVD in gastric adenocarcinoma plays an important role in the occurrence and development of gastric cancer.