论文部分内容阅读
目的:探讨不同临床类型和病理类型的腺性膀胱炎与癌前病变的关系。方法:对40例腺性膀胱炎进行临床分型和病理分型,10例正常膀胱黏膜组织作为对照,采用免疫组织化学SABC法检测不同类型腺性膀胱炎和正常膀胱黏膜组织P53和Ki67的表达情况,并利用全自动显微镜及图像分析系统对免疫组化染色结果进行图像采集及分析。结果:临床分型中,乳头型和肠腺瘤型腺性膀胱炎P53和Ki67阳性表达明显高于慢性炎症型和滤泡型腺性膀胱炎(P<0.05)。病理分型中,肠上皮型和前列腺上皮型腺性膀胱炎P53和Ki67阳性表达与移行上皮型比较差异有统计学意义。结论:临床分型中,乳头型和肠腺瘤型腺性膀胱炎可能为癌前病变。病理分型中,肠上皮型和前列腺上皮型腺性膀胱炎可能为癌前病变。因此腺性膀胱炎是否具有恶变潜能应将二者相结合综合考虑,乳头型和肠腺瘤型腺性膀胱炎若伴有肠上皮化生或前列腺上皮化生则发生癌变的概率更大。
Objective: To investigate the relationship between cystitis glandularis and precancerous lesions of different clinical types and pathological types. Methods: Forty cases of glandular cystitis were classified by clinical type and pathological type. Ten cases of normal bladder mucosa were used as control. Immunohistochemical SABC method was used to detect the expression of P53 and Ki67 in different types of cystitis glandula and normal bladder mucosa The situation, and the use of automatic microscopy and image analysis system for immunohistochemical staining results of image acquisition and analysis. Results: The positive expression rates of P53 and Ki67 in papillary and enteric adenoma were significantly higher than those in chronic inflammatory and follicular cystitis (P <0.05). Pathological classification, intestinal epithelial and prostatic cystitis glandularis P53 and Ki67 positive expression and transitional epithelial type difference was statistically significant. Conclusion: The clinical classification of papillary and enteric adenoma cystitis may be precancerous lesions. Pathological classification, intestinal epithelial glandular cystitis and prostate gland may be precancerous lesions. Therefore, cystitis cystitis malignant potential should be combined with the two should be considered, papillary and enteric adenomatous cystitis associated with intestinal metaplasia or prostate epithelial metaplasia is more likely to have cancer.