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目的:探讨大豆异黄酮和维生素E混合制剂对老龄大鼠的抗氧化作用。方法:将48只雌性老龄大鼠按血清丙二醛水平随机分为低剂量组、中剂量组、高剂量组和老龄对照组,连续灌胃60 d后,测定血清中丙二醛(MDA)含量及超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-PX)活性。结果:与老龄对照组比较,低、中、高剂量组血清MDA含量显著降低;低、中、高剂量组血清SOD活性显著升高;中剂量组和高剂量组GSH-Px活性明显升高。结论:大豆异黄酮和维生素E混合制剂对老龄大鼠具有抗氧化功能。
Objective: To investigate the antioxidative effect of a mixture of soy isoflavone and vitamin E on aged rats. Methods: 48 female aged rats were randomly divided into low dose group, medium dose group, high dose group and aging control group according to the serum malondialdehyde level. After continuous intragastric administration for 60 days, the levels of malondialdehyde (MDA) Content and superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) activity. Results: Compared with the old control group, serum MDA levels were significantly decreased in low, middle and high dose groups; SOD activity was significantly increased in low, middle and high dose groups; GSH-Px activity was significantly increased in middle dose group and high dose group. Conclusion: The combination of soy isoflavone and vitamin E has anti-oxidative function in the aged rats.