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目的 :探讨内镜止血联用大剂量洛赛克治疗消化性溃疡大出血的临床价值。方法 :对 2 2例溃疡病大出血患者进行内镜治疗 ,然后将内镜止血成功的 2 1例继续抑酸治疗 ,10例用大剂量洛赛克 ,11例用常规剂量西米替丁。结果 :内镜即刻止血成功 2 1例 ,失败 1例。 2 1例内镜止血成功后发生再出血 5例。 10例联用大剂量洛赛克无再出血病例发生。 11例联用西米替丁 ,有 5例发生再出血 ,后经改用大剂量洛赛克治疗后 ,在 48小时内再出血停止。两药再出血率经x2 检验有显著性差异 (P <0 .0 5 )。结论 :内镜止血可迅速缩短溃疡病大出血的病程 ,大剂量洛赛克能迅速提高胃内pH ,持续维持胃高 pH ,保护胃十二指肠粘膜 ,巩固内镜止血疗效 ,防治内镜止血后发生近期再出血。两者联用 ,大大提高了溃疡病人大出血的治愈水平 ,值得在临床推广使用
Objective: To investigate the clinical value of endoscopic hemostasis combined with high dose of Losec in the treatment of hemorrhagic peptic ulcer. Methods: Twenty-two patients with bleeding from ulcer disease were treated with endoscopic therapy. Then 21 patients with successful endoscopic hemostasis were treated with acid suppression therapy, 10 with high dose of Losec and 11 with conventional dose of cimetidine. Results: Endoscopic immediate hemostasis was successful in 21 cases, 1 case of failure. There were 5 cases of rebleeding after 21 cases of successful endoscopic hemostasis. 10 cases combined with high-dose Losec no recurrence of bleeding occurred. 11 cases combined with cimetidine, 5 cases of rebleeding, after switching to high-dose Losec treatment, rebleeding stopped within 48 hours. Two drugs rebleeding rate by x2 test was significantly different (P <0. 05). Conclusion: Endoscopic hemostasis can shorten the course of bleeding from ulcer disease. High dose Losec can rapidly increase gastric pH, maintain high gastric pH, protect gastroduodenal mucosa, consolidate endoscopic hemostasis, prevent endoscopic hemostasis Shortly after the occurrence of rebleeding. Combined use of the two, greatly improving the cure rate of bleeding ulcer patients, it is worth to promote the use of the clinical