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目的探讨慢性乙型肝炎患者不同肝功能状况与胃黏膜病变程度的相关性。方法对30例首次发病的慢性乙型肝炎患者进行胃镜检查,同时取病理并与其肝功能指标、乙型肝炎病毒(HBV)DNA定量、凝血酶原时间(PT)进行了相关性分析。结果慢性乙型肝炎患者胃黏膜病变表现多样,以慢行浅表性胃窦炎为主,病理显示主要为轻度及中度慢性炎症。单因素分析表明性别、年龄、血清HBVDNA在轻度及中度慢性胃炎组无明显差异(P>0.05),肝功能指标中白蛋白(ALB)、PT在两组中的差异具有统计学意义(P<0.05)。应用Logistic回归方程进行多因素分析表明,PT延长是慢性乙型肝炎患者胃黏膜病变程度的预测因子,P=0.049,OR=2.105(95%可信区间1.004～4.414)。结论随肝功能损伤加重,胃黏膜病变程度加重,PT可作为胃黏膜病变程度的预测因素。
Objective To investigate the correlation between different liver function status and gastric mucosal lesions in patients with chronic hepatitis B. Methods Thirty patients with first-onset chronic hepatitis B were examined by gastroscopy. Pathology was also analyzed. The correlations were analyzed with liver function, hepatitis B virus (HBV) DNA, and prothrombin time (PT). Results The gastric mucosal lesions in patients with chronic hepatitis B manifested a variety of symptoms, mainly chronic superficial antral gastritis. The pathological findings are mainly mild and moderate chronic inflammation. Univariate analysis showed that gender, age, serum HBVDNA in mild and moderate chronic gastritis group had no significant difference (P> 0.05), liver function indicators of albumin (ALB), PT in the two groups was statistically significant difference P <0.05). Multivariate analysis using Logistic regression equation showed that PT prolongation was a predictor of gastric mucosal lesions in patients with chronic hepatitis B (P = 0.049, OR = 2.105 (95% confidence interval 1.004-4.414). Conclusion With the aggravation of hepatic function, the degree of gastric mucosal lesion is aggravated. PT can be used as a predictor of gastric mucosal lesion degree.