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类风湿性关节炎(Rheumatoid arthritis,RA)是一种侵犯关节滑膜,进而破坏关节软骨和骨质,致劳动力丧失甚至严重影响患者生活质量的疾病。早期诊断、早期正规治疗对RA病情控制及改善预后至关重要,但如何在早期对RA患者的病情及预后作出判断却是临床上的一个难题。长期以来人们一直期望能找到早期诊断RA的方法,在血清学方面,人们发现抗核周因子(Anfiperinuclear factor,APF)等~([1])几种特异性抗体
Rheumatoid arthritis (RA) is a kind of disease that invades the synovial joint, and then destroys the articular cartilage and bone, causing loss of labor and even seriously affecting the quality of life of patients. Early diagnosis, early formal treatment of RA disease control and improve prognosis is crucial, but how to judge the condition and prognosis of RA patients in early stage is a clinical problem. People have long been looking forward to finding an early diagnosis of RA. In serology, several specific antibodies such as Anfiper in nuclear factor (APF) [~ 1] have been found