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目的 :观察中药肝豆片Ⅰ号对肝豆状核变性 (HLD)患者胆汁微量元素的影响。方法 :3 2例HLD患者口服肝豆片Ⅰ号治疗 4周 ,采用十二指肠引流术留取治疗前后HLD患者的胆汁B液 ,并与非HLD患者 3 0例胆汁作为对照组。运用原子吸收分光光度计分别测定两组患者胆汁中铜、锌、铁、钙等元素的含量。结果 :治疗前HLD患者胆汁中铜、铁含量及铜 /锌比值显著低于非HLD对照组 (P <0 0 1或P <0 0 5) ,钙含量显著高于非HLD对照组 (P <0 0 1) ,而锌含量两组差异无显著性 ;治疗后治疗组胆汁排铜量较治疗前显著增加 (P <0 0 5) ,而锌、铁、钙含量及铜 /锌比值无明显变化。结论 :胆汁排铜障碍是导致HLD患者体内铜蓄积的机制之一 ,肝豆片Ⅰ号能促进HLD患者胆汁排铜
Objective: To observe the effect of Gadou No. Ⅰ on bile trace elements in patients with hepatolenticular degeneration (HLD). Methods: Forty-two patients with HLD were treated with OGD-Ⅰ for 4 weeks. Duodenal drainage was used to collect bile B fluid in patients with HLD before and after treatment and 30 patients with non-HLD as control. Atomic absorption spectrophotometer were used to determine the contents of copper, zinc, iron, calcium and other elements in the two groups of patients. Results: The contents of copper, iron and copper / zinc in the bile of HLD patients before treatment were significantly lower than those in the non-HLD control group (P <0.01 or P <0.05), and the calcium levels were significantly higher than those in the non-HLD control group (P < (P <0.05), while the contents of zinc, iron, calcium and copper / zinc had no significant difference between the two groups Variety. CONCLUSION: Biliary blockade of copper is one of the mechanisms leading to copper accumulation in HLD patients. Liver-bean tablet Ⅰ can promote the secretion of bile copper in HLD patients