目的:依据药理学相关理论,设计并合成一种新型阿魏酸NO供体衍生物。方法:以阿魏酸为原料,经过羧基的酯化,溴化物取代以及硝化反应,合成阿魏酸NO供体衍生物。结果:共得到两个目标产物,分别是4-硝酸酯丙氧基-3-甲氧基苯丙烯酸甲酯和4-硝酸酯丁氧基-3-甲氧基苯丙烯酸甲酯,结构经1H NMR和质谱进行了确证。结论:首次合成一种新的阿魏酸NO供体衍生物。 OBJECTIVE: To design and synthesize a novel NO donor derivative of ferulic acid based on the theory of pharmacology. Methods: Ferulic acid was used as the starting material to synthesize ferulic acid NO donor derivatives through esterification of carboxyl groups, bromide substitution and nitration reaction. Results: Two target products were obtained, which were methyl 4-nitropropoxy-3-methoxyphenyl acrylate and methyl 4-nitobutoxybutoxy-3-methoxybenzyl acrylate respectively. The structures were characterized by 1H NMR and mass spectrometry were confirmed. CONCLUSION: A novel NO donor derivative of ferulic acid was synthesized for the first time.