一般都相信灰黄霉素局部应用是无效的。但近来有报告其软膏制剂有效,已有两篇评述提出局部应用灰黄霉素可能是一种有用的治疗方法。由于发展了在人类皮肤内测量小量灰黄霉素适当的灵敏技术,已可能显示当给健康人局部应用一次含2％微粒灰黄霉素的软膏后,所产生的皮肤药物浓度比口服后所测得者高数倍。作者应用2％灰黄霉素软膏、1％发癣退霜(作为阳性对照)与软膏基质(作为阴性对照)作了双盲试验。治疗期间为3周,皮损全部清除或明显进步而镜检及培养阴性者为治疗成功,而 It is generally believed that griseofulvin topical application is ineffective. Recently, however, there have been reports of effective ointment preparations, and two reviews have suggested that topical application of griseofulvin may be a useful treatment. Due to the development of appropriate sensitive techniques for measuring small amounts of griseofulvin in human skin, it has been possible to show that when topical application of an ointment containing 2% particulate griseofulvin to healthy individuals produces a higher dermal drug concentration than after oral administration Measured several times higher. The authors performed a double-blind trial with 2% griseofulvin ointment, 1% hair ringworm retreat (as a positive control) and ointment base (as a negative control). During the treatment period of 3 weeks, the skin lesions were all cleared or significantly improved, and microscopic examination and culture negative for the treatment of success, and