死亡相关蛋白激酶(DAPK)是一种凋亡的正性调节因子,可促进肿瘤细胞的分化并抑制肿瘤的转移,被认为是肿瘤的抑制剂。DAPK基因启动子超甲基化或蛋白表达异常在多种肿瘤中均可观察到,并与分级分期及预后呈一定相关,表明其在肿瘤的发生及进展中发挥一定作用,在肿瘤的早期诊断、评价预后及基因靶向治疗等方面有重要意义。现就DAPK与肿瘤的诊断与治疗的研究进展予以一综述。 Death-associated protein kinase (DAPK), a positive regulator of apoptosis, promotes tumor cell differentiation and inhibits tumor metastasis, and is considered as a tumor suppressor. DAPK gene promoter hypermethylation or abnormal protein expression in a variety of tumors can be observed, and with the staging and prognosis of a certain correlation, suggesting that it plays a role in the occurrence and progression of the tumor in the early diagnosis of the tumor , Evaluation of prognosis and gene-targeted therapy and other aspects of great significance. Now DAPK and tumor diagnosis and treatment of research progress are reviewed.