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二巯基丁二酸(DMSA)是Owen等于1949年首次合成的双巯基化合物.1957年,我国梁猷毅等报告该药对酒石酸锑钾中毒有很好的疗效.从那以后的10-20年间,我国和苏联的学者们对该药的药理、毒理、临床应用效果等方面进行了广泛的研究.现该药已成为我国临床常用的金属中毒解毒药.欧美一些国家则是在七十年代才开始对DMSA发生兴趣的.本文主要就DMSA的药理作用、解毒效果及口服应用等问题综述如下. 一、DMSA的药理作用 DMSA为含有双巯基的化合物,它对金属中毒的解毒作用机理与二巯基丙醇(BAL)和二疏基丙磺酸钠(DMPS)相同,即竞争性地解除金属毒物对
Dimercaptosuccinic acid (DMSA) is the first double-mercapto compound Owen equals to 1949. In 1957, Liang et al reported that the drug had a good effect on the antimony potassium tartrate poisoning.From the next 10-20 years, China And Soviet scholars conducted extensive research on the pharmacology, toxicology and clinical application effects of the drug, etc. Now the drug has become the commonly used metal poisoning antidote in our country .In some countries in Europe and the United States, it started in the seventies DMSA interested in this article mainly on the pharmacological effects of DMSA, detoxification effect and oral application and other issues are summarized as follows.First, the pharmacological effects of DMSA DMSA is a double thiol-containing compounds, its detoxification mechanism of metal poisoning and two mercaptopropionic Alcohols (BAL) are the same as sodium dithiosulfonate (DMPS), which competitively neutralizes metal toxins