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目的：探讨脑电双频指数（ BIS）对老年患者异丙酚全凭静脉麻醉的监测效果。方法选取2014年6月至2015年6月行异丙酚全凭静脉麻醉的老年患者110例，按照 BIS 监测方案分为两组，每组55例。研究组行 BIS 监测异丙酚全凭静脉麻醉，对照组则对 BIS 值进行遮蔽完成异丙酚全凭静脉麻醉，比较两组麻醉效果。结果研究组手术开始、术中、麻醉结束、完成手术时 BIS 值高于对照组，差异有统计学意义（P <0.05）。研究组 OAA/ S 评分、丙泊酚用量、手术及麻醉清醒时间均少于对照组，差异有统计学意义（P <0.05）。结论老年患者全凭静脉麻醉行 BIS 监测可有效降低OAA/ S 评分、麻醉药物用量，缩短手术时间，患者清醒快，值得临床推广应用。“,”Objective To investigate the effect of BIS monitoring on total intravenous anesthesia with propofol. Methods From June 2014 to June 2015,110 elderly patients with total intravenous anesthesia with propofol were selected and divided into two groups according to the BIS monitoring program with 55 cases in each group. The research group was given total intravenous anesthesia with propofol for BIS monitoring,while the control group was completed to cover the BIS value of propofol by intravenous anesthesia,and compare the effect of two groups of anesthesia. Results BIS value of the research group at the begining of the operation,the operation,the end of anesthesia and the completion of the operation were higher than those of the control group,the differences were significant(P < 0. 05). OAA/ S score,the dosage of propofol,surgery and anesthesia waking hours in research group were less than those in control group,the differences were significant(P < 0. 05). Conclusion Total in-travenous anesthesia in elderly patients with BIS monitoring can effectively reduce the OAA/ S score,anesthetic drug dosage, shorten the operation time and patients’awake time,so it is worthy of clinical application.