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目的 :探讨细胞膜结构和功能改变在肥胖引起儿童高血压发病机制中的作用。方法 :测定了 10 4例 [正常对照 (NT) 3 7例 ,正常血压肥胖 (ONT) 3 4例 ,高血压肥胖 (OHT) 3 3例 ] 12～ 16岁中学儿童的Na+ K+ ATP酶和Ca2 + ATP酶活性、膜Ca2 + 结合力和磷脂含量。结果 :ONT组和OHT组的Na+ K+ ATP酶和Ca2 + ATP酶活性及膜Ca2 + 结合力显著低于NT组 ,OHT组又显著低于ONT组 ,且与平均动脉压 (MAP)显著相关。OHT组磷脂含量显著低于NT组和ONT组 ,且与MAP显著相关 ,而在NT组和ONT组之间无显著差异。结论 :细胞膜Na+ K+ ATP酶和Ca2 + ATP酶活性及膜Ca2 + 结合力减低可能在肥胖诱导儿童高血压的发病机制中起重要作用。
Objective: To investigate the role of cell membrane structure and function changes in the pathogenesis of hypertension-induced hypertension in children. Methods: The levels of Na + K + ATPase and Ca2 + in children aged 12 ~ 16 years old were measured in 10 4 cases [normotensive (NT) 37 cases, normotensive obese (ONT) 34 cases and hypertensive obesity (OHT) + ATPase activity, membrane Ca2 + binding capacity and phospholipid content. Results: The activities of Na + K + ATPase and Ca2 + ATPase and membrane Ca2 + binding ability of ONT group and OHT group were significantly lower than those of NT group. OHT group was significantly lower than that of ONT group and significantly correlated with mean arterial pressure (MAP). The phospholipid content of OHT group was significantly lower than that of NT group and ONT group, and significantly correlated with MAP, but there was no significant difference between NT group and ONT group. Conclusion: The decrease of membrane Na + K + ATPase and Ca2 + ATPase activity and membrane Ca2 + binding ability may play an important role in the pathogenesis of obesity-induced hypertension in children.