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目的 探讨促红细胞生成素 (EPO)与系统性红斑狼疮 (SLE)贫血的关系。方法 测定 36例SLE贫血患者血清EPO(s EPO)水平 ,分析其与血红蛋白 (Hb)的相关性。结果 SLE贫血患者s EPO水平4 4 2 ( 7 8～ 192 2 )U/L ,明显高于正常对照组 4 2 ( 0 74～ 18 4 )U/L及SLE非贫血患者 6 8( 1 2～ 2 9 7)U/L ,但低于慢性失血所致缺铁性贫血 (IDA)患者 93( 15 5～ 389 2 )U/L(P <0 0 5 )。SLE贫血组和IDA组Hb与s EPO水平呈负相关 (P <0 0 5 )。结论 SLE贫血患者s EPO水平相对降低可能是SLE贫血的原因之一。
Objective To investigate the relationship between erythropoietin (EPO) and systemic lupus erythematosus (SLE) anemia. Methods The levels of serum EPO (s EPO) in 36 patients with SLE anemia were measured and their correlation with hemoglobin (Hb) was analyzed. Results The level of s EPO in patients with SLE anemia was 442 (78 ~ 192 2) U / L, which was significantly higher than that of the control group (42 (0 74 ~ 184) U / L and SLE patients without anemia 297) U / L, but lower than 93 (15 5 ~ 389 2) U / L (P <0 05) in patients with iron deficiency anemia (IDA) due to chronic blood loss. The levels of Hb and s EPO in SLE anemia group and IDA group were negatively correlated (P <0.05). Conclusion The relative reduction of s EPO level in patients with SLE anemia may be one of the causes of SLE anemia.