目的观察并探讨通过替米沙坦联合硝苯地平治疗老年顽固性高血压gerontic refracrory hypertension,GRH)的临床疗效。方法选择自2013年5月~2015年8月在本院接受治疗的GRH患者39例,作为观察组,另外选取此前一年半内在我院治疗的GRH患者38例作为对照组。其中,对照组患者曾给予常规的硝苯地平加复方卡托普利口服治疗,而观察组患者给予替米沙坦联合硝苯地平口服治疗。记录两组患者治疗前后不同时间段的收缩压和舒张压,并统计其治疗后的总体疗效。结果观察组患者在治疗3周以后的收缩压和舒张压明显低于对照组,差异具有统计学意义(P<0.05);观察组和对照组的总有效率分别为94.9%(37/39)和76.3%(29/38),差异具有统计学意义(P<0.05)。结论通过替米沙坦联合硝苯地平治疗能明显改善GRH患者的病情,疗效显著,在临床上值得推广应用。 Objective To observe and discuss the clinical efficacy of telmisartan combined with nifedipine in the treatment of gerontic refracrory hypertension (GRH) in elderly patients with refractory hypertension. Methods From May 2013 to August 2015, 39 patients with GRH treated in our hospital were selected as the observation group and 38 patients with GRH treated in our hospital in the previous year and a half were selected as the control group. Among them, the control group of patients had given conventional nifedipine plus captopril oral treatment, while patients in the observation group were given telmisartan combined with nifedipine oral treatment. The systolic and diastolic blood pressure were recorded at different time points before and after treatment in both groups, and the overall curative effect after treatment was recorded. Results The systolic and diastolic blood pressure of the observation group was significantly lower than that of the control group after 3 weeks of treatment, the difference was statistically significant (P <0.05); the total effective rates of the observation group and the control group were 94.9% (37/39) And 76.3% (29/38) respectively, the difference was statistically significant (P <0.05). Conclusion Telmisartan combined with nifedipine treatment can significantly improve the condition of patients with GRH, the effect is significant, it is worth to promote the clinical application.