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目的探讨早期宫颈癌宫旁组织转移患者临床特点及危险因素。方法回顾性分析太和医院收治的900例ⅠA2~ⅡA2期早期宫颈癌患者的临床资料,所有患者入院后均接受广泛性子宫切除联合盆腔淋巴结清扫术,统计宫颈癌宫旁组织转移例数,总结患者临床特点,分析早期宫颈癌患者宫旁转移的危险因素。结果 (1)900例早期宫颈癌患者发生宫旁组织转移55例,转移率为6.11%,以宫旁软组织转移率最高(3.11%),宫旁脉管次之(1.67%);(2)单因素分析发现:宫颈癌患者发生宫旁组织转移与患者临床分期、肿瘤最大直径、鳞状细胞癌抗原(SCC-Ag)水平、肿瘤浸润深度、脉管浸润、手术切缘、淋巴结转移、累及宫体、累及阴道均有其相关性(P<0.05);(3)多因素分析发现:浸润深度、脉管侵犯、手术切缘、淋巴结转移是早期宫颈癌患者发生宫旁组织转移的独立危险因素(P<0.05),其中淋巴结转移相关度最高。结论早期宫颈癌患者宫旁组织转移发生率较低,肿瘤浸润深度、脉管侵犯、手术切缘阳性、淋巴结转移均为宫颈癌患者发生宫旁组织转移的危险因素。
Objective To investigate the clinical features and risk factors of early cervical cancer patients with paracancerous tissue metastasis. Methods The clinical data of 900 patients with stage ⅠA ~ ⅡA2 early cervical cancer admitted to Taihe Hospital were retrospectively analyzed. All patients underwent radical hysterectomy combined with pelvic lymphadenectomy after admission, and the number of cases of uterine paracancerous tissue metastasis was analyzed. The clinical characteristics of patients, analysis of early cervical cancer risk factors for uterine metastasis. Results (1) Among the 900 cases of early cervical cancer, 55 cases of uterine tissue metastasis occurred, the metastasis rate was 6.11%, the highest rate of uterine soft tissue metastasis (3.11%) and the second uterine vessel (1.67%); (2) Univariate analysis showed that uterine paracancerous tissue metastasis and clinical stage, maximum tumor diameter, squamous cell carcinoma antigen (SCC-Ag) level, tumor invasion depth, vascular invasion, surgical margin, lymph node metastasis, (P <0.05). (3) Multivariate analysis showed that depth of invasion, vascular invasion, surgical margins and lymph node metastasis were independent risk of uterine tissue metastasis in patients with early cervical cancer Factor (P <0.05), and the correlation degree of lymph node metastasis was the highest. Conclusion The incidence of uterine tissue metastasis in patients with early cervical cancer is low, the depth of tumor invasion, vascular invasion, positive surgical margins and lymph node metastasis are the risk factors of uterine tissue metastasis in patients with cervical cancer.