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目的:通过研究胃舒散中重金属铋在大鼠血液中的分布代谢情况,为研究该物质在体内的蓄积情况提供实验依据。方法:取健康大鼠,灌服胃舒散混悬液,分别于给药前及给药后5,10,15,20,25,30,40,60,120,180,240 min尾静脉采血。用电感耦合等离子体质谱仪(ICP-MS)检测铋含量,进行分析。结果:测得数据显示铋的血药浓度在0.5 h左右达到高峰,达峰浓度在15μg.L-1左右,然后快速下降,7 h降至较低水平。铋在大鼠体内的吸收半衰期14.691 min,消除半衰期293.422 min,铋在大鼠体内的血浆药物总清除率1 571.044 L.min-1.kg-1。AUC 2 063.515μg.L-1.min-1。结论:铋在大鼠体内的药代动力学模型符合一房二室模型。
Objective: To study the distribution and metabolism of heavy metal glycosides in rat blood in Weishusan and provide experimental evidence for studying the accumulation of this substance in vivo. METHODS: Healthy rats were given Maweisanshu suspension. Gavage blood was collected before and 5, 10, 15, 20, 25, 30, 40, 60, 120, 180, 240 minutes after administration. The indole content was measured by inductively coupled plasma mass spectrometry (ICP-MS) and analyzed. RESULTS: The measured data showed that the blood drug concentration of sputum reached a peak around 0.5 h, reached a peak concentration of around 15 μg.L-1, then decreased rapidly, and dropped to a lower level at 7 h. The absorption half-life of Chinese wolfberry in rats was 14.691 min, the elimination half-time was 293.422 min, and the total plasma drug clearance rate of Chinese wolfberry in rats was 1 571.044 L.min-1.kg-1. AUC 2 063.515 μg.L-1.min-1. Conclusion: The pharmacokinetic model of earthworms in rats fits the one-bedroom two-compartment model.