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目的探讨硝苯地平联合硫酸镁治疗妊娠高血压综合征的临床疗效。方法选取2013年1月—2016年1月玉山县仙岩镇中心卫生院收治的妊娠高血压综合征患者78例,随机分为研究组与对照组,各39例。对照组给予单纯硫酸镁治疗,研究组在对照组的基础上加用硝苯地平片口服治疗。治疗7d后,比较两组患者的临床疗效、血压改善情况[收缩压(SBP),舒张压(DBP)]、24h尿蛋白定量及母婴结局。结果研究组总有效率高于对照组,差异有统计学意义(P<0.05)。治疗前两组患者DBP、SBP及24h尿蛋白总量比较,差异无统计学意义(P>0.05);治疗后,研究组SBP、DBP及24h尿蛋白总量低于对照组,差异有统计学意义(P<0.05);治疗后两组患者SBP、DBP及24h尿蛋白总量低于治疗前,差异有统计学意义(P<0.05)。两组患者新生儿死亡率比较,差异无统计学意义(P>0.05);研究组宫缩乏力、产后出血、胎儿宫内窘迫及早产发生率均低于对照组,差异有统计学意义(P<0.05)。结论硝苯地平联合硫酸镁治疗妊娠高血压综合征的临床疗效确切,能有效解除血管痉挛,降低血压、控制蛋白尿,改善氧代谢功能及患者的临床症状。
Objective To investigate the clinical efficacy of nifedipine combined with magnesium sulfate in the treatment of pregnancy induced hypertension syndrome. Methods From January 2013 to January 2016, 78 cases of pregnancy induced hypertension syndrome admitted to Xiyan Central Hospital of Yushan County were randomly divided into study group and control group, with 39 cases in each group. The control group was treated with magnesium sulfate alone. The study group was treated with nifedipine tablets orally on the basis of the control group. After 7 days of treatment, the clinical efficacy, improvement of blood pressure (systolic blood pressure (SBP) and diastolic blood pressure (DBP)], urinary protein excretion in 24 hours and maternal and infant outcomes were compared between the two groups. Results The total effective rate of the study group was higher than that of the control group, the difference was statistically significant (P <0.05). Before treatment, DBP, SBP and 24-hour urinary protein in the two groups had no significant difference (P> 0.05). After treatment, the total SBP, DBP and 24h urinary protein in the study group were lower than those in the control group (P <0.05). After treatment, the total SBP, DBP and 24 h urinary protein in the two groups were lower than before treatment, the difference was statistically significant (P <0.05). There was no significant difference in neonatal mortality between the two groups (P> 0.05). The incidence of uterine inertia, postpartum hemorrhage, fetal distress and preterm birth in the study group were all lower than those in the control group (P <0.05). Conclusion Nifedipine combined with magnesium sulfate in the treatment of pregnancy-induced hypertension syndrome is effective and can effectively relieve vasospasm, reduce blood pressure, control proteinuria, improve oxygen metabolism and clinical symptoms of patients.