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给人大肠癌Ｈ９０１和ＳＷ１１１６ＮＣ裸小鼠模型接种同系半裸鼠的胸腺，经２－３周免疫效应潜伏期后，直径约１ｃｍ的瘤块逐渐缩小，在９周内完全消失。光镜检查发现，肿瘤细胞在瘤块内逐渐缩小，被浸润的淋巴细胞和间质分割成孤岛状，在５周未肿瘤细胞基本消失，继而是一个肿瘤残存结构被逐步完全吸收的过程。透射电镜检查发现肿瘤细胞的死亡与细胞凋亡现象有关，即肿瘤细胞的核染色质浓聚，沿核膜分布。在先天性Ｔ细胞免疫缺陷的ＮＣ裸小鼠中经胸腺移植后部分重建裸鼠Ｔ细胞功能杀灭实体肿瘤的模型对进一步研究免疫系统抗肿瘤作用的机理有一定的意义。
The thymus glands of human nude mice were inoculated with human colorectal cancer H901 and SW1116NC nude mouse models. After a incubation period of 2-3 weeks, tumors with a diameter of approximately 1 cm gradually shrank and completely disappeared within 9 weeks. Light microscopic examination revealed that the tumor cells gradually narrowed within the tumor mass, and the infiltrated lymphocytes and interstitium were divided into islands. At the 5th week, the tumor cells did not disappear, followed by a process in which the remaining tumor structure was gradually completely absorbed. Transmission electron microscopy revealed that the death of tumor cells was related to apoptosis, that is, the nuclear chromatin of tumor cells was concentrated and distributed along the nuclear membrane. A model of partially reconstructing the T cell function of a nude mouse to kill a solid tumor in a nude mouse with congenital T cell immunodeficiency in a nude mouse has certain significance for further studying the mechanism of the anti-tumor effect of the immune system.