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目的:探讨甲氨蝶呤联合米非司酮治疗对异位妊娠血人绒毛膜促性腺激素(β-HCG)及副反应影响。方法:回顾性分析2010年12月至2013年12月本院诊治的110例异位妊娠患者的临床资料,按照不同治疗方案分为两组,对照组55例行甲氨蝶呤治疗,研究组55例患者行甲氨蝶呤联合米非司酮治疗,观察并比较两组患者疗效时间指标、血β-HCG与包块大小改善情况及副反应。结果:研究组临床症状消失、尿β-HCG转阴、血β-HCG恢复及住院时间均优于对照组,差异均有统计学意义(P<0.01);两组血β-HCG与包块大小均较治疗前显著改善,且研究组改善程度更佳,组内、组间比较差异均有统计学意义(P<0.05或P<0.01);两组患者副反应发生率比较差异无统计学意义(P>0.05)。结论:异位妊娠行甲氨蝶呤联合米非司酮治疗对血β-HCG及副反应均具有积极影响,可以增强临床疗效。
Objective: To investigate the effects of methotrexate combined with mifepristone on blood human chorionic gonadotropin (β-HCG) and side effects in ectopic pregnancy. Methods: The clinical data of 110 patients with ectopic pregnancy diagnosed and treated in our hospital from December 2010 to December 2013 were retrospectively analyzed. The patients were divided into two groups according to the different treatment regimens and the control group 55 methotrexate. The study group 55 patients methotrexate combined with mifepristone treatment, observation and comparison of two groups of patients efficacy time index, blood β-HCG and mass improvement and side effects. Results: The clinical symptoms of the study group disappeared, urine β-HCG negative, blood β-HCG recovery and hospital stay were better than the control group, the difference was statistically significant (P <0.01) (P <0.05 or P <0.01). There was no significant difference in the incidence of side effects between the two groups Significance (P> 0.05). Conclusion: Methotrexate combined with mifepristone in ectopic pregnancy has a positive effect on blood β-HCG and side effects, which can enhance the clinical efficacy.