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[目的]比较国产与进口生长抑素在治疗食管-胃底静脉破裂出血中的疗效及成本-效果比(C/E)。[方法]52例食管-胃底静脉破裂出血患者被随机分为国产生长抑素组(28例)和进口生长抑素组(24例),应用药物经济学的成本-效果分析方法,对其疗效和成本-效果比进行比较、评价。[结果]国产生长抑素组和进口生长抑素组有效率分别为78.6%、87.5%,平均止血时间分别为(28.2±10.6)h、(23.6±9.0)h,2组差异无统计学意义(P>0.05)。国产生长抑素组C/E为49.87,明显低于进口生长抑素组的77.15。[结论]从药物经济学角度,国产生长抑素相对低廉,治疗食管-胃底静脉曲张破裂出血的成本-效果比优于进口生长抑素。
[Objective] To compare the curative effect and cost-effect ratio (C / E) of domestic and imported somatostatin in the treatment of esophageal-gastric fundus rupture hemorrhage. [Methods] Fifty-two patients with esophageal-gastric fundus rupture hemorrhage were randomly divided into domestic somatostatin group (n = 28) and imported somatostatin group (n = 24). The cost-effectiveness analysis method Efficacy and cost-effectiveness than the comparison, evaluation. [Results] The effective rates of domestic somatostatin and imported somatostatin were 78.6% and 87.5%, respectively, and the mean hemostatic time were (28.2 ± 10.6) and (23.6 ± 9.0) h respectively, with no significant difference between the two groups (P> 0.05). Domestic somatostatin C / E was 49.87, significantly lower than the import of somatostatin 77.15. [Conclusion] From the point of view of pharmacoeconomics, domestic somatostatin is relatively inexpensive and the cost-effectiveness of esophageal-gastric variceal hemorrhage is better than that of imported somatostatin.