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目的探讨血浆炎症因子在急性冠状动脉综合征(ACS)后焦虑发病中的作用。方法检测101例 ACS 住院患者发病72 h 内血浆 IL-6、TNFα、超敏 C 反应蛋白(hsCRP)水平,同时并完成标准化问卷调查表《医院焦虑抑郁量表-焦虑分表》并计分,并记录患者的人口统计学资料。结果ACS 后焦虑与非焦虑患者的血浆 TNFα水平差异有统计学意义(M=0.68 pg/ml,焦虑组与对照组平均秩次44.55比61.70,P=0.004),而血浆 hsCRP、IL-6水平在两组中差异无统计学意义。结论ACS 后焦虑不增加患者体内的炎症反应。
Objective To investigate the role of plasma inflammatory factors in the pathogenesis of anxiety after acute coronary syndrome (ACS). Methods The levels of plasma IL-6, TNFα and hsCRP in 101 hospitalized patients with ACS were detected and the standardized questionnaire “anxiety and depression scale-anxiety scale” was completed and scored. And record the patient’s demographic information. Results The levels of plasma TNFα in patients with and without anxiety after ACS were significantly different (M = 0.68 pg / ml, mean rank 44.55 and 61.70 in anxiety and control groups, P = 0.004), while plasma levels of hsCRP and IL-6 There was no significant difference between the two groups. Conclusions Post-ACS anxiety does not increase the inflammatory response in patients.