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盆腹腔粘连发生是一个涉及细胞、细胞因子、细胞外基质(extracellular matrix,ECM)及其降解酶类等多种因素、多个环节的相互作用和相互调节的病理生理过程。目前研究发现盆腹腔粘连形成的主要原因是腹膜损伤,ECM合成及降解调节失衡,病理结局表现为ECM过度沉积,最后形成粘连。而结缔组织生长因子(connective tissue growth factor,CTGF)具有促进ECM合成的作用,基质金属蛋白酶抑制剂-1(tissue inhibitor of metalloproteinase-1,TIMP-1)具有抑制ECM降解的作用,二者表达异常可能与盆腹腔粘连形成相关。
Intraperitoneal adhesions are a pathophysiological process involving many factors, such as cells, cytokines, extracellular matrix (ECM) and its degrading enzymes, and their interactions and interactions. The current study found that the formation of abdominal adhesions in the main reason is peritoneal injury, ECM synthesis and degradation regulation imbalance, the pathological outcome of ECM over-deposition, the final formation of adhesions. The connective tissue growth factor (CTGF) can promote the synthesis of ECM. The inhibitor of metalloproteinase-1 (TIMP-1) has the effect of inhibiting the degradation of ECM, and the expression of CTGF is abnormal May be related to the formation of abdominal adhesions.