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目的:探讨苯磺酸左旋氨氯地平片与厄贝沙坦的联合应用对老年难治性高血压患者临床疗效的影响及其可能机制。方法:选取我院确诊并治疗的老年难治性高血压患者72例作受试者,按随机数字表法分为两组,对照组36例予以利尿药联合厄贝沙坦进行血压调控,治疗组36例在对照组基础上予联合苯磺酸左旋氨氯地平片2.5 mg日一次进行治疗。观察两组患者的临床疗效,监控患者血压情况,比较治疗前后患者血清同型半胱氨酸(Hcy)、TNF-α及IL-6水平的变化。结果:对照组总有效率低于治疗组(P<0.05);与对照组比较,治疗组患者血压控制情况较好,治疗后血清Hcy、TNF-α及IL-6水平降低,差异具有统计学意义(P<0.05)。结论:苯磺酸左旋氨氯地平片与厄贝沙坦的联合应用可有效控制老年难治性高血压患者的血压、尽早恢复患者血压稳定,可能与其降低血清Hcy、TNF-α、IL-6的水平有关。
Objective: To investigate the effect of levamlodipine besylate combined with irbesartan on the clinical efficacy of elderly patients with refractory hypertension and its possible mechanism. Methods: Seventy-two elderly patients with refractory hypertension diagnosed and treated in our hospital were selected and divided into two groups according to the random number table. The control group received diuretic combined with irbesartan for blood pressure control. Group 36 cases based on the control group combined with levamisodipine besylate tablets 2.5 mg once a day for treatment. To observe the clinical curative effect of two groups of patients, monitor the blood pressure of patients and compare the changes of serum homocysteine (Hcy), TNF-α and IL-6 before and after treatment. Results: The total effective rate in the control group was lower than that in the treatment group (P <0.05). Compared with the control group, the blood pressure control was better in the treatment group and the levels of Hcy, TNF-α and IL-6 were decreased after treatment Significance (P <0.05). Conclusion: The combined application of levamlodipine besylate and irbesartan can effectively control the blood pressure in elderly patients with refractory hypertension, as soon as possible to restore the patient’s blood pressure stability, may be associated with its lower serum Hcy, TNF-α, IL-6 The level of the relevant.