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目的:研究黏液溶解药物——重组人类脱氧核糖核酸酶(rhDNase)对重症毛细支气管炎患儿的疗效。方法:48例重症毛细支气管炎婴儿随机分为两组,一组给予rhDNase喷雾剂2 mg,1次/d,共5天;另一组给予安慰剂。观察两组主要症状、体征消失时间及住院时间。结果:两组主要症状、体征消失时间及住院时间比较差异均有统计学意义。治疗组有效率高于对照组,差异有统计学意义。结论:rhDNase能有效改善重症毛细支气管炎患儿的呼吸道阻塞情况。
Objective: To study the curative effect of mucin-dissolving drug-rhDNase on children with severe bronchiolitis. Methods: Forty-eight severe bronchiolitis infants were randomly divided into two groups. One group was given rhDNase spray 2 mg once daily for 5 days. The other group was given placebo. The main symptoms, signs disappear time and hospital stay were observed. Results: There were significant differences between the two groups in the main symptoms, the disappearance of signs and the length of hospital stay. The treatment group was more effective than the control group, the difference was statistically significant. Conclusion: rhDNase can effectively improve the airway obstruction in children with severe bronchiolitis.