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观察栝蒌薤白汤对肺纤维化大鼠支气管肺泡灌洗液 (BALF)中层粘连蛋白 (LN)、Ⅲ型前胶原(PC Ⅲ )含量的影响。用平阳霉素复制大鼠肺纤维化模型后 ,用药组每天灌胃栝蒌薤白汤 ,2 8d后处死 ,观察各组大鼠肺病理组织学改变。结果 :模型组大鼠肺泡炎及纤维化程度、BALF中LN及PC Ⅲ含量均明显高于正常对照组及用药组 (P <0 0 5 )。说明栝蒌薤白汤能明显减轻平阳霉素所致的大鼠肺泡炎及纤维化程度 ,抑制BALF中LN、PC Ⅲ含量的增高。
Observe the effect of Qibai Decoction on the levels of laminin (LN) and type III procollagen (PC III) in bronchoalveolar lavage fluid (BALF) in rats with pulmonary fibrosis. After lung fibrosis model was replicated with pingyangmycin, the treatment group was treated with Qibai Decoction every day and sacrificed 28 days later. The histopathological changes of lungs in each group were observed. Results: The alveolitis and fibrosis in the model group, LN and PC III contents in the BALF were significantly higher than those in the normal control group and the drug group (P<0.05). The results showed that Qibai Decoction can significantly reduce the degree of pulmonary alveolitis and fibrosis caused by Pingyangmycin and inhibit the increase of LN and PC III in BALF.