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目的通过分析狼疮性肾炎(LN)患者的超敏C反应蛋白水平与并发左心室肥厚(LVH)的相关性,探讨高血清超敏C反应蛋白水平导致的炎性反应在LN患者并发LVH中的作用。方法 503例LN患者为研究对象,按有无并发LVH症分为单纯LN组(287例)和LN合并LVH组(216例)。以患者一般资料及相关生化免疫检测指标为分析指标,运用统计学方法对LN患者并发LVH的危险因素和独立危险因素进行分析。结果 LN合并LVH组患者年龄、超敏C反应蛋白水平、左室重量指数、尿酸水平均高于单纯LN组,血红蛋白、肾小球滤过率则低于单纯LN组,比较差异具有统计学意义(P<0.05)。LN患者并发LVH可能与患者年龄、超敏C反应蛋白水平、尿酸水平、血红蛋白、肾小球滤过率等因素相关。以左室重量指数为因变量,以患者年龄、超敏C反应蛋白水平、尿酸水平、血红蛋白、肾小球滤过率等危险因素为自变量进行多元逐步回归分析,超敏C反应蛋白水平与左心室重量指数呈现正相关关系(OR=8.833,P<0.05)。超敏C反应蛋白水平为LN患者并发LVH的独立高危因素。结论 LN患者并发LVH与患者血清超敏C反应蛋白高水平相关,血清超敏C反应蛋白是LN患者并发LVH的独立危险因素,其产生机制与高血清超敏C反应蛋白水平导致的炎性反应相关,对血清超敏C反应蛋白水平进行积极干预在防止LN患者并发LVH中有着重要的意义,可预防患者心血管并发症的发生。
OBJECTIVE: To investigate the correlation between high-sensitivity C-reactive protein levels and left ventricular hypertrophy (LVH) in patients with lupus nephritis (LN) and to explore the inflammatory response induced by high serum C-reactive protein in LN patients with LVH effect. Methods A total of 503 patients with LN were divided into simple LN group (287 cases) and LN combined with LVH group (216 cases) with and without LVH. Based on the general data of patients and related biochemical and immuno-detection indexes, the risk factors and independent risk factors of LVH complicated with LN were analyzed by using statistical methods. Results Age, high-sensitivity C-reactive protein, left ventricular mass index, and uric acid in patients with LN combined with LVH were significantly higher than those in patients with LN alone, hemoglobin and glomerular filtration rate were significantly lower than those in LN alone (P <0.05). Patients with LN complicated with LVH may be related to the patient’s age, high-sensitivity C-reactive protein, uric acid, hemoglobin and glomerular filtration rate. The left ventricular mass index was taken as the dependent variable and the risk factors such as patient’s age, high-sensitivity C-reactive protein level, uric acid level, hemoglobin and glomerular filtration rate were used as independent variables to conduct multiple stepwise regression analysis. Left ventricular mass index showed a positive correlation (OR = 8.833, P <0.05). High-sensitivity C-reactive protein is an independent risk factor for LN in patients with LVH. Conclusions LVH complicated with LN in patients with high level of serum high sensitive C-reactive protein is associated with high serum levels of C-reactive protein in patients with LN complicated by LVH, its mechanism of production and high serum C-reactive protein level caused by inflammatory reaction Related, positive serum levels of hypersecretion C-reactive protein in the prevention of LN complicated by LVH has an important significance, can prevent the occurrence of cardiovascular complications in patients.