脂肪性肝病(fatty liver disease,FLD)是由各种原因引起的,一组以肝细胞大泡性脂肪变为病理特征,并可进展为脂肪性肝炎和肝纤维化的异质性疾病,包括酒精性肝病(alcoholic liver disease,ALD)、非酒精性脂肪性肝病(nonalcoholic fatty liver disease,NAFLD)及特殊原因所致脂肪肝等三大类型。随着人口的老龄化、肥胖人群的增加及酒精的滥用,FLD患者愈来愈多,并成为终末期肝病的重要原因。脂肪肝尤其是非酒精性脂肪性肝炎(nonalcoholic steatohepatitis,NASH)与糖尿病及心血管 Fatty liver disease (FLD) is caused by a variety of causes, a group of hepatocytic bullous lipoid into pathological features and can progress to heterogeneous disease of steatohepatitis and liver fibrosis, including Alcoholic liver disease (ALD), nonalcoholic fatty liver disease (NAFLD) and fatty liver caused by special causes are the three major types. With population aging, increased obesity and alcohol abuse, FLD patients more and more, and become an important cause of end-stage liver disease. Fatty liver, especially nonalcoholic steatohepatitis (NASH) and diabetes mellitus and cardiovascular