加味三子养亲汤治疗小儿咳嗽随机平行对照研究

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[目的]观察加味三子养亲汤治疗小儿咳嗽疗效。[方法]使用随机平行对照方法,将60例住院患者按就诊顺序编号随机分为两组。对照组30例青霉素,2.5万U/kg,每12小时给药l次,肌注。地塞米松,2~20mg/次,2次/d,静注;或5%葡萄糖注射液稀释,2~6h重复给药至病情稳定,大剂量连续给药不超过72h,静滴。氨茶碱,2~4mg/kg,1次/d,5%~25%葡萄糖注射液稀释,静注。治疗组30例加味三子养亲汤(苏子15g,菜菔子炒、白芥子、款冬花、紫菀、杏仁各9g,甘草3g,桔梗6g,炙麻黄、川贝各10g)。1剂/d,水煎150mL,4次/d(睡前1h,餐后30min)。连续治疗7d为1疗程。观测临床症状、不良反应。连续治疗2疗程,判定疗效。[结果]治疗组治愈17例,好转11例,无效2例,总有效率93.33%。对照组治愈10例,好转11例,无效9例,总有效率70.00%。治疗组疗效优于对照组(P<0.05)。[结论]加味三子养亲汤治疗小儿咳嗽效果显著,值得推广。 [Objective] To observe the effect of Modified Sanzi Yangzi Decoction on pediatric cough. [Methods] Using randomized parallel control method, 60 inpatients were randomly divided into two groups according to the order of treatment. Control group, 30 cases of penicillin, 25000 U / kg, administered once every 12 hours, intramuscular injection. Dexamethasone, 2 ~ 20mg / time, 2 times / d, intravenous injection; or 5% glucose injection dilution, repeated administration of 2 ~ 6h to stable condition, continuous administration of large doses of not more than 72h, intravenous infusion. Aminophylline, 2 ~ 4mg / kg, 1 / d, 5% ~ 25% glucose injection dilution, intravenous injection. Treatment group, 30 cases of modified three sons raise pro-soup (Su 15g, stir fried vegetables, mustard seed, coltsfoot flower, aster, almond 9g, licorice 3g, Campanulaceae 6g, Sunburn Ephedra, Chuanbei each 10g). 1 dose / d, decoction 150mL, 4 times / d (bedtime 1h, postprandial 30min). Continuous treatment 7d for a course of treatment. Observed clinical symptoms, adverse reactions. Continuous treatment of 2 courses to determine the efficacy. [Results] The treatment group cured 17 cases, improved in 11 cases, 2 cases, the total effective rate 93.33%. The control group was cured in 10 cases, improved in 11 cases, ineffective in 9 cases, the total effective rate was 70.00%. The treatment group was better than the control group (P <0.05). [Conclusion] Modified Sanzi Yang-Qin Decoction treatment of children with significant cough, it is worth promoting.
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