目的研究血浆脂蛋白 (a) [Lp(a) ]和载脂蛋白 (a) [Lp(a) ]与急性脑梗死患者发病的关系。 方法急性脑梗死患者 45例为观察研究对象 ,36例非脑血管病患者为对照组 ,测定两组的Lp(a)与Apo(A)血浆水平进行比较。 结果观察组患者的Lp(a)较对照组明显升高 ,Apo(A)较对照组明显下降 ,两组具有显著性差异 (P <0 .0 1 )。 结论血浆Lp(a)升高与Apo(A)下降是急性脑梗死患者发病的独立危险因素。 Objective To study the relationship between plasma lipoprotein (a) [Lp (a)] and apolipoprotein (a) [Lp (a)] in patients with acute cerebral infarction. Methods Forty-five patients with acute cerebral infarction were observed, and 36 patients with non-cerebrovascular disease were selected as control group. Plasma levels of Lp (a) and Apo (A) were compared between the two groups. Results The Lp (a) in the observation group was significantly higher than that in the control group. The Apo (A) level in the observation group was significantly lower than that in the control group. There was a significant difference between the two groups (P <0.01). Conclusions Elevated plasma Lp (a) and decreased Apo (A) are independent risk factors for acute cerebral infarction.