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目的制备川利明涂剂,并观察其止痒祛痛的临床效果。方法将盐酸川芎嗪、盐酸利多卡因与盐酸苯海拉明组成复方,制成涂剂,并应用高效液相色谱法测定其中盐酸利多卡因的含量。选择临床不同原因所致的瘙痒或合并疼痛,在痒、痛最严重的皮区涂布该制剂,然后随访记录疗效。结果川利明涂剂为无色半透明的黏稠液体,其中盐酸利多卡因含量为5%;患者15例涂布后均取得明显效果,其中以老年性瘙痒、异物接触过敏以及烧伤疤痕组织形成期间发痒的疗效最佳。结论皮肤瘙痒或合并疼痛局部应用川利明涂剂不失为一种安全、有效的新方法。
OBJECTIVE To prepare chuan-li-ming agent and observe its clinical effect of relieving itching and relieving pain. Methods Tetramethylpyrazine hydrochloride, lidocaine hydrochloride and diphenhydramine hydrochloride were compounded to make paints, and the content of lidocaine hydrochloride was determined by high performance liquid chromatography. Select the clinically different causes of itching or pain associated with the pain, itching, pain in the most severe skin area coated with the preparation, and then follow-up record the effect. Results Chuan-li-ming agent is a colorless and translucent viscous liquid, which lidocaine hydrochloride content of 5%; 15 patients after coating have achieved significant results, including senile pruritus, foreign body contact allergies and burn scar tissue during the formation The best itchy effect. Conclusions It is a safe and effective new method to topically apply promethazine and pruritus or pain in combination.