催乳素(PRL)作为神经内分泌、免疫分子在干燥综合征(SS)发病中的作用渐受关注。PRL可通过促进腺上皮细胞抗原提呈功能、改变外周血及局部T淋巴细胞亚群间平衡、增高CD4/CD8细胞比值、刺激B淋巴细胞活化产生免疫球蛋白和自身抗体等环节致自身免疫过程加重。目前的观点倾向于SS腺体局部以Th1占优势。PRL是否通过调节淋巴细胞分泌细胞因子类型参与SS发病有待进一步研究。 Prolactin (PRL) as a neuroendocrine, immune molecules in the pathogenesis of Sjogren’s syndrome (SS) increasingly attention. PRL can induce autoimmune processes such as immunoglobulin and autoantibodies by promoting the antigen presenting function of glandular epithelial cells, altering the balance between peripheral blood and local T lymphocyte subsets, increasing the ratio of CD4 / CD8 cells, stimulating the activation of B lymphocytes Increase. The current point of view is that the SS gland tends to predominantly Th1. Whether PRL participates in the pathogenesis of SS by regulating lymphocyte-secreting cytokine types remains to be further studied.