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目的观察左旋氨氯地平对脑梗死合并轻度高血压患者颈内动脉血管功能的治疗效果。方法将82例颈内动脉系统脑梗死并轻度高血压患者,随机分为治疗组42例和对照组40例。在相同的危险因素下,治疗组和对照组每天分别使用左旋氨氯地平2.5 mg和氨氯地平5 mg治疗1年。观察患者的血压、颈内动脉内膜厚度、狭窄支数、副作用等指标。结果治疗后,各组中血压、颈内动脉厚度、狭窄支数与治疗前比较,差异有统计学意义(P<0.01)。两组间治疗前后,血压、颈内动脉内膜和狭窄支数比较,差异无统计学意义(P>0.05);但两组间副反应比较差异有统计学意义(P<0.05)。结论左旋氨氯地平可以降低患者血压,并有抗颈内动脉粥样硬化和改善血管功能的作用。
Objective To observe the therapeutic effect of levamlodipine on the function of internal carotid artery in patients with cerebral infarction complicated with mild hypertension. Methods 82 patients with cerebral infarction and mild hypertension were randomly divided into treatment group (n = 42) and control group (n = 40). The same risk factors, the treatment group and the control group were treated with levamlodipine 2.5 mg and amlodipine 5 mg for 1 year. Observe the patient’s blood pressure, carotid artery intima-media thickness, stenosis count, side effects and other indicators. Results After treatment, the blood pressure, carotid artery thickness and stenosis count in each group were significantly different from those before treatment (P <0.01). There was no significant difference in blood pressure, internal carotid artery intima and stenosis count between the two groups before and after treatment (P> 0.05), but there was significant difference between the two groups (P <0.05). Conclusion L-amlodipine can reduce blood pressure in patients with anti-carotid atherosclerosis and improve vascular function.