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目的探讨形成早期梅毒皮损的可能机制。方法分别用常规病理、银染及免疫组化法检测30例早期梅毒皮损组织中的病理变化、梅毒螺旋体和Th1/Th2细胞因子的表达。结果一期梅毒硬下疳和二期梅毒的结节、斑块、丘疹、脓疱等皮损中有典型的梅毒组织学结构和梅毒螺旋体,而斑疹损害中无典型的梅毒组织学结构和梅毒螺旋体。硬下疳中Th1型细胞因子表达占优势,二期梅毒患者的结节、斑块、丘疹、脓疱等皮损中Th1/Th2型细胞因子的表达视梅毒螺旋体感染时间长短而不同,Th2型细胞因子的表达主要见于感染时间较长的皮损,而斑疹中Th2型细胞因子表达与梅毒螺旋体的感染时间无关。结论二期梅毒斑疹损害可能因机体的变态反应引起。
Objective To explore the possible mechanism of forming early syphilis lesions. Methods The pathological changes, the expression of Treponema pallidum and Th1 / Th2 cytokines were detected by routine pathology, silver staining and immunohistochemistry in 30 cases of early stage syphilis. Results A typical Syphilis histology and Treponema pallidum were found in the first stage of syphilis and second stage syphilis nodules, plaques, papules, pustules and other lesions, while there was no typical syphilis histology and syphilis in the lesions Spirochetes. The expression of Th1-type cytokines in the dorsal root ganglion predominated. The expression of Th1 / Th2 type cytokines in the lesional lesions such as nodules, plaques, papules and pustules in patients with secondary syphilis was determined by the duration of infection with Treponema pallidum. Th2 type cells The expression of factor was mainly found in the lesion with longer infection time, but the expression of Th2 cytokines in the rash was not related to the infection time of Treponema pallidum. Conclusion The secondary syphilis may be caused by the body’s allergy.