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观察 3 0例慢性吸烟者和 1 5例正常人在使用中药贴剂前后血浆皮质醇及血浆 ﹀-内啡肽水平。结果显示慢性吸烟者的血浆皮质醇及血浆 ﹀-内啡肽明显高于正常组 ;自然戒断期 ,戒烟组的血浆皮质醇明显升高 ,而血浆﹀-内啡肽明显降低 ;治疗戒断期 ,慢性吸烟者血浆﹀-内啡肽恢复正常水平 ,而血浆皮质醇有所下降 ,但仍高于正常组 ;正常组在贴敷中药贴剂前后血浆皮质醇及血浆﹀-内啡肽无明显变化。提示中药贴剂戒烟可能是通过改善内源性阿片肽系统及下丘脑 -垂体 -肾上腺轴的功能达到戒烟的效果。
Observe the levels of plasma cortisol and plasma >-endorphin in 30 cases of chronic smokers and 15 cases of normal persons before and after using traditional Chinese medicine patch. The results showed that plasma cortisol and plasma >-endorphin in chronic smokers were significantly higher than in the normal group; in the natural withdrawal period, plasma cortisol was significantly increased in the smoking cessation group, and plasma>-endorphin was significantly decreased; During the period, chronic plasma smokers returned to normal plasma levels of endorphins, while plasma cortisol levels decreased, but remained higher than normal subjects. Plasma cortisol and plasma levels of endorphins in the normal group before and after the application of traditional Chinese medicine patches were not increased. obvious change. It is suggested that smoking cessation may be achieved by improving the function of the endogenous opioid peptide system and the hypothalamus-pituitary-adrenal axis.